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CAS No.: 16980-89-5

布拉地新钠盐 Catalog No. CSN10499

Synonyms: Dibutyryl cAMP sodium salt;DBcAMP sodium salt

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation.

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靶点选择性

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实验方案

技术信息

生物活性

描述PKA is a ubiquitous cellular kinase, also known as cAMP-dependent protein kinase (cAMP), and it is well-established that plays an important role in regulating several functions of cell processes, including regulation of glycogen, sugar, and lipid metabolism^[3]. Dibutyryl-cAMP is a cell-permeable PKA activator that functions by preferentially activating endogenous cAMP. In vitro assays, Dibutyryl-cAMP was found to significantly suppress TNF-a production in a dose-dependent manner, with IC50 values of 247, 28.9, and 25.4 μM, respectively in RAW264.7 cells^[4]. Additionally, rat hepatocytes were cultured with cAMP agonists dibutyryl-cAMP inhibits Nitric oxide synthesis and inducible nitric oxide synthase (iNOS) expression through effects on the iNOS promoter region and NF-kB-binding activity^[5]. In hepatocytes, Dibutyryl-cAMP can prevent tumor necrosis factor α plus acti-nomycin D (TNFα/ActD)-induced apoptosis via a PKA-dependent mechanism^[6]. In vivo model, Dibutyryl-cAMP showed a distinct anti-fibrotic effect via PKA/p-CREB/CBP signaling. Treatment of Dibutyryl-cAMP resulted in the decrease of the number and size of silicosis nodules, inhibition of myofibroblast differentiation, and extracellular matrix deposition^[7]. Moreover, 4 days intra-peritoneal injections of bucladesine (600 nM/mouse) significantly reversed zinc chloride- and led acetate-induced avoidance memory retention alterations compared to control animals^[8].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
mouse RAW264.7 cells	-	Function assay	4 h	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA, IC50=28.9 μM	11000020
mouse S49 cells	500 μM	Cytotoxicity assay	20-49 h	Cytotoxicity against HGPRTase-deficient mouse S49 cells assessed as growth inhibition at 500 uM after 20 to 49 hrs by time-course study	221658

动物研究
剂量
Cat: 1 mg/kg - 6 mg/kg^[3] (i.v.) Rat: 0.1 mg/kg^[4] (i.t.)

给药途径
i.v., i.t.

动物研究
剂量	Cat: 1 mg/kg - 6 mg/kg^[3] (i.v.) Rat: 0.1 mg/kg^[4] (i.t.)
给药途径	i.v., i.t.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0351 mL
- 10.1757 mL
- 20.3514 mL
- 5 mM
- 0.4070 mL
- 2.0351 mL
- 4.0703 mL
- 10 mM
- 0.2035 mL
- 1.0176 mL
- 2.0351 mL

技术信息

CAS号

16980-89-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H23N5NaO8P

运输

蓝冰

分子量

491.37

别名

Dibutyryl cAMP sodium salt;DBcAMP sodium salt

溶解度

DMSO	96.0 mg/mL (195.4 mM) warming
Water	95.0 mg/mL (193.3 mM) warming
Ethanol	19.0 mg/mL (38.7 mM) warming

动物实验配方

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